Substrate: Alpha-2A adrenergic receptor (G protein coupled receptor)
Seq-ID: P08913 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
thioesterase binding,
epinephrine binding,
alpha2-adrenergic receptor activity,
protein homodimerization activity,
protein kinase binding,
alpha-2C adrenergic receptor binding,
norepinephrine binding,
heterotrimeric G-protein binding,
alpha-1B adrenergic receptor binding,
protein heterodimerization activity		 receptor complex,
cytoplasm,
basolateral plasma membrane,
integral to plasma membrane		 actin cytoskeleton organization,
intestinal absorption,
positive regulation of cell migration,
cellular component movement,
Rho protein signal transduction,
negative regulation of epinephrine secretion,
positive regulation of cytokine production,
positive regulation of epidermal growth factor receptor activity,
cellular response to hormone stimulus,
negative regulation of calcium ion-dependent exocytosis,
positive regulation of membrane protein ectodomain proteolysis,
inhibition of adenylate cyclase activity by G-protein signaling pathway,
negative regulation of insulin secretion,
cellular response to glucose stimulus,
negative regulation of lipid catabolic process,
negative regulation of norepinephrine secretion,
activation of protein kinase B activity,
negative regulation of calcium ion transport via voltage-gated calcium channel activity,
positive regulation of MAP kinase activity,
negative regulation of cAMP biosynthetic process,
positive regulation of cell proliferation,
activation of phospholipase C activity,
glucose homeostasis,
positive regulation of potassium ion transport,
positive regulation of wound healing
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 232 IAKRRTRVPPSRRGPDAVAAP PKC_group 11732925
LTP
0.44
 - 7tm_1
0.75
 - medium
S 296 RDTDALDLEESSSSDHAERPP - 7876239
LTP
0.23
 - 7tm_1
0.87
 - medium
S 297 DTDALDLEESSSSDHAERPPG - 7876239
LTP
0.33
 - 7tm_1
0.87
 - medium
S 298 TDALDLEESSSSDHAERPPGP - 7876239
LTP
0.89
 - 7tm_1
0.88
 - medium
S 299 DALDLEESSSSDHAERPPGPR - 7876239
LTP
0.89
 - 7tm_1
0.88
 - medium

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